Uptake-1 Carrier Downregulates in Parallel with the -Adrenergic Receptor Desensitization in Rat Hearts Chronically Exposed to High Levels of Circulating Norepinephrine: Implications for Cardiac Neuroimaging in Human Cardiomyopathies
نویسنده
چکیده
1Service Hospitalier Frédéric Joliot, Département de Recherche Médicale, Direction des Sciences du Vivant-Commissariat à l’Energie Atomique, Orsay, France; 2Institut National pour la Santé et la Recherche Médicale, Unité 400, Université de Médecine, Créteil, France; 3Fédération de Cardiologie, Centre Hospitalo-Universitaire Henri Mondor-Université Paris XII, Créteil, France; and 4Service de Médecine Nucléaire, Centre Hospitalo-Universitaire Henri Mondor-Université Paris XII, Créteil, France
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Chamber-specific alterations of norepinephrine uptake sites in cardiac hypertrophy.
The present study investigated local differences of sympathetic activation and sympathetic neuroeffector defects in nonhypertrophied right and hypertrophied left ventricles in a rat model with renin-induced pressure overload [TG(mREN2)27]. As judged from the depletion of myocardial norepinephrine stores, sympathetic activation was more pronounced in the left than in the right ventricles. In add...
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